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has result
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Betacoronavirus
viral RNA-directed RNA polymerase
complex
early infected cell destruction
in coronavirus infection
natural killer cell
interferon regulatory factor
7 (human)
toll-like receptor 3 signaling
pathway
Toll-like receptor 3 (human)
natural killer cell-mediated
apoptotic process of infected
cells in coronavirus infection
type I interferon signaling
pathway
interferon alpha/beta receptor
1 (human)
interferon alpha/beta receptor
2 (human)
B cell
plasma cell
Cytotoxic T cell activation
via T cell receptor contact
with antigen bound to MHC
molecule on antigen presenting
cell in coronavirus infection
plasmacytoid dendritic cell
interferon alpha (human)
interferon beta (human)
MAVS complex assembly in coronavirus
infection
MDA-5 signaling pathway
RIG-I signaling pathway
antiviral innate immune response
receptor RIG-I (human)
PKR signaling pathway
mitochondrial antiviral-signaling
protein (human)
serine/threonine-protein kinase
TBK1 (human)
interferon regulatory factor
3 (human)
tyrosine-protein kinase JAK1
(human)
STAT1 signal transduction
pathway
signal transducer and activator
of transcription 1-alpha/beta
(human)
interleukin-6-mediated signaling
pathway
interleukin-6 (human)
tumor necrosis factor (human)
macrophage
interferon gamma (human)
interleukin-8 (human)
neutrophil
interleukin-17-mediated signaling
pathway
interleukin-17A (human)
negative regulation of T-helper
1 cell activation in coronavirus
infection
T-helper 2 cell
interleukin-4(human)
interleukin-5 (human)
interleukin-10 (human)
interleukin-13 (human)
T-helper 17 cell
negative regulation of type
II interferon production in
coronavirus infection
positive regulation of cytotoxic
T cell activation in coronavirus
infection
T-helper 1 cell
interleukin-2 (human)
spike glycoprotein (Betacoronacirus)
vesicle
endosome membrane
viral envelope
molecule
cell surface
cathepsin L1 (human)
cathepsin B (human)
toll-like receptor 7 signaling
pathway
Toll-like receptor 7 (human)
cytoplasmic pattern recognition
receptor signaling pathway
in response to virus
TLR signaling pathway
pattern recognition receptor
signaling pathway
toll-like receptor 8 signaling
pathway
Toll-like receptor 8 (human)
T cell mediated removing infected
cell in coronavirus infection
2'-5'-oligoadenylate synthase
1 (human)
interferon-induced, double-stranded
RNA-activated protein kinase
(human)
interferon-induced GTP-binding
protein Mx1 (human)
macrophage antigen presentationin
coronavirus infection
E-selectin (human)
granzyme-mediated apoptotic
signaling pathway
inflammatory cell
monocyte
viral structural protein
production in coronavirus
infection
spike glycoprotein (SARS-CoV-2)
envelope small membrane protein
(SARS-CoV-2)
membrane protein (SARS-CoV-2)
nucleoprotein (SARS-CoV-2)
spike protein S2 (Betacoronavirus)
changing viral inflammation-anti-inflammation
balance in coronavirus infection
cytotoxic T cell
CD4-positive helper T cell
cytotoxic T cell degranulation
in coronavirus infection
adaptive immune memory response
in coronavirus infection
memory B cell
memory T cell
interleukin-7 (human)
interleukin-15 (human)
inflammatory macrophage
membrane attack complex
blood coagulation pathway
platelet activation in coronavirus
infection
platelet
P-selectin (human)
continuant
rash
heat
tissue
biological membrane
blood vessel
dendritic cell
histamine
Dolor
bradykinin
Prostaglandin E2
prostaglandin
fever
multicellular organism
leukotriene B4
leukotriene
swelling symptom
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine
negative regulation of type
I interferon production in
COVID-19
protein 3b (SARS-CoV-2)
host translation inhibitor
nsp1 (SARS-CoV-2)
replicase polyprotein 1a (SARS-CoV-2)
replicase polyprotein 1ab
(SARS-CoV-2)
viral polyprotein 1a processing
in COVID-19
viral polyprotein1ab processing
in COVID-19
non-structural protein 3 (SARS-CoV-2)
3C-like proteinase (SARS-CoV-2)
RIG-I signaling in COVID-19
MDA-5 signaling in COVID-19
PKR signaling in COVID-19
TLR3 signaling in COVID-19
TBK1 activation in COVID-19
natural killer cell mediated
immunity in COVID-19
natural killer cell-mediated
apoptotic process of infected
cells in COVID-19
IRF7 activation in COVID-19
type I interferon production
in COVID-19
immunoglobulin-mediated neutralization
in COVID-19
Fc-gamma receptor signaling
in COVID-19
removing infected cell in
adaptive immunity in COVID-19
helper T cell enhancement
of adaptive immune respons
in COVID-19
B cell activation involved
in adaptive immune response
in COVID-19
negative regulation of viral
action in COVID-19
positive regulation of MHC
class I biosynthetic process
in COVID-19
antigen processing and presentation
of exogenous peptide antigen
via MHC class I in COVID-19
cytotoxic T cell apoptotic
process in COVID-19
cytotoxic T cell degranulation
in COVID-19
natural killer cell apoptotic
processin COVID-19
removing infected cell in
COVID-19
early removing infected cell
in COVID-19
phagocytosis in COVID-19
IRF3 activation in COVID-19
JAK signaling in COVID-19
STAT1 signaling in COVID-19
negative regulation of viral
gene expression in COVID-19
negative regulation of viral
genome replication in COVID-19
antigen processing and presentation
of exogenous peptide antigen
via MHC class II in COVID-19
T-helper cell differentiation
in COVID-19
phagocytosis by inflammatory
macrophage in COVID-19
neutrophil mediated cytotoxicity
in COVID-19
T-helper 2 cell cytokine production
in COVID-19
T-helper 2 cell differentiation
in COVID-19
T-helper 2 cell activation
in COVID-19
T-helper 1 cell cytokine production
in COVID-19
IL-2 signaling in COVID-19
spike protein S1 (SARS-CoV-2)
neuropilin-1 (human)
angiotensin-converting enzyme
2 (human)
spike protein S2 (SARS-CoV-2)
spike protein S2\' (SARS-CoV-2)
transmembrane protease serine
2 (human)
FURIN (human)
SARS-CoV-2
1-phosphatidyl-1D-myo-inositol
3,5-bisphosphate
phosphoinositide
cleavage of viral spike S
protein 2 in COVID-19
Plpro gene expression in COVID-19
early infected cell destruction
in COVID-19
antigen presentationin COVID-19
receiving viral signal in
pattern recognition signaling
pathway in COVID-19
TLR7 signaling in COVID-19
interferon-beta production
in COVID-19
increasing interferon-beta
level in COVID-19
interferon-alpha production
in COVID-19
type I interferon signaling
in COVID-19
cellular response to type
I interferon in COVID-19
negative regulation of viral
translation in COVID-19
TLR8 signaling in COVID-19
cell damage recognition in
COVID-19
cytolysis in COVID-19
production of molecular mediator
of immune response in COVID-19
positive regulation of viral
RNA catabolic process in COVID-19
negative regulation of viral
entry into host cell in COVID-19
negative regulation of virion
attachment to host cell in
COVID-19
TLR signaling in COVID-19
increasing virus resitance
in COVID-19
T-helper 1 type immune response
in COVID-19
T-helper 1 cell activation
in COVID-19
T-helper 1 cell differentiation
in COVID-19
cellular immune response in
COVID-19
positive regulation of immune
cell activation in COVID-19
macrophage differentiation
in COVID-19
binding of pattern recognition
receptor to PAMPs in COVID-19
humoral immune response in
COVID-19
T-helper 2 type immune response
in COVID-19
inflammation-anti-inflammation
imbalance in COVID-19
B cell mediated immunity in
COVID-19
activation of membrane attack
complex in COVID-19
phagocytosis by inflammatory
macrophagein COVID-19
neutrophil clearance in COVID-19
negative regulation of TBK1
activation in COVID-19
Negative regulation of type
I interferon signaling pathway
in COVID-19
Negative regulation of TBK1
phosphorylation in COVID-19
suppression by virus of host
translation in COVID-19
positive regulation of viral
genome replication in COVID-19
negative regulation of type
III interferon production
in COVID-19
C-C motif chemokine 3 (human)
C-C motif chemokine 2 (human)
interleukin-1 beta (human)
hypoxia-inducible factor 1-alpha
(human)
Negative regulation of ISG15
modification by small protein
conjugation in COVID-19
ubiquitin-like protein ISG15
(human)
Negative regulation of IRF3
modification by small protein
conjugation in COVID-19
Negative regulation of nuclear
transport in COVID-19
negative regulation of INFB1
expression in COVID-19
Negative regulation of ISG15
gene expression in COVID-19
Negative regulation of OAS1
gene expression in COVID-19
interferon-beta production
(very low) in COVID-19
negative regulation of inflammatory
response in COVID-19
neutrophil apoptotic process
in COVID-19
anti-inflammatory cytokine
production in COVID-19
Negative regulation of EIF2AK2
gene expression in COVID-19
Negative regulation of MX1
gene expression in COVID-19
complement
granulocyte colony-stimulating
factor (human)
T cell
GM-CSF production in COVID-19
granulocyte-macrophage colony-stimulating
factor (human)
blood clot
tissue factor (human)
C-reactive protein (human)
ferritin complex (human)
increasing lactate dehydrogenase
concentration in COVID-19
L-lactate dehydrogenase A
chain (human)
vascular endothelial growth
factor A (human)
SARS-CoV-2 S binding to human
ACE2 on nasal epitherial
cell in COVID-19
disturbances of sensation
of smell and taste
opsonization in COVID-19
complement activation, alternative
pathway in COVID-19
vascular cell adhesion protein
1 (human)
tumor necrosis factor-mediated
signaling pathway
disintegrin and metalloproteinase
domain-containing protein
17 (human)
angiotensin II
angiotensin-activated signaling
pathway
type-1 angiotensin II receptor
(human)
release of anaphylatoxin in
COVID-19
positive regulation of phagocytosis
in COVID-19
IL-1 signal transduction pathway
thrombin-activated receptor
signaling pathway
collagen
chemokine (C-C motif) ligand
2 signaling pathway
interleukin-2-mediated signaling
pathway
plasma kallikrein-kinin cascade
plasma kallikrein (human)
chemokine (C-C motif) ligand
3 signaling pathway
chemokine (C-X-C motif) ligand
10 signaling pathway
C-X-C motif chemokine 10 (human)
type III interferon signaling
pathway
chemokine (C-C motif) ligand
10 production in COVID-19
chemokine-mediated signaling
pathway
chemokine (C-X-C motif) ligand
8 signaling pathway
tissue-resident macrophage
inflammatory cytokine-mediated
signaling pathway
two pore calcium channel protein
2 (human)
1-phosphatidylinositol 3-phosphate
5-kinase (human)
platelet activating factor
biosynthetic process (very
high) in severe COVID-19
platelet activation (very
high) in severe COVID-19
fibrinolysis (very low) in
severe COVID-19
negative regulation of fibrinolysisin
severe COVID-19
viral replication complex
formation and maintenance
(very high) in severe COVID-19_2
subgenomic negative stranded
viral mRNA biosynthetic process(very
high) in severe COVID-19
full length negative stranded
viral mRNA biosynthetic process
(very high) in severe COVID-19
IL-1beta processing in severe
COVID-19
caspase-1 (human)
mitochondrial dysfunction
(very high) in severe COVID-19
release of DNA from mitochondria
in severe COVID-19
mitochondrial DNA
IL-17 signaling in severe
COVID-19
autoimmune responsein severe
COVID-19
T-helper 17 cell differentiation
in severe COVID-19
T-helper 17 cell cytokine
production in severe COVID-19
positive regulation of HIF1A
gene expression (very high)
in severe COVID-19
Expression of HIF1A (very
high) in severe COVID-19
increasing blood CRP concentration
(very high) in severe COVID-19
increasing oxidative stress
(very high)in severe COVID-19
cellular damage (very high)
in severe COVID-19
negative regulation of inflammatory
response (very low) in severe
COVID-19
neutrophil apoptotic process
(low) in severe COVID-19
neutrophil clearance (low)
in severe COVID-19
tissue regeneration (very
high) in severe COVID-19
anti-inflammatory cytokine
production (low) in severe
COVID-19
inflammation-anti-inflammation
imbalance in severe COVID-19
apoptotic cell clearance (low)
in severe COVID-19
apoptotic process (very high)
in severe COVID-19
cell damage recognition in
severe COVID-19
T cell exhaustion (very high)
in severe COVID-19
negative regulation of T cell
mediated immunity (very high)
in severe COVID-19
Negative regulation of T cell
proliferation (very high)
in severe COVID-19
programmed cell death protein
1 (human)
pore formation in membrane
of other organismin severe
COVID-19
gasdermin-D (human)
hypofunction of vasodilation
in severe COVID-19
hypofunction of mitochondrial
fatty acid beta-oxidation
in severe COVID-19
T cell activation (very high)
in severe COVID-19
natural killer cell cytokine
production in severe COVID-19
inflammasome activation (very
high) in severe COVID-19
synthesis or release of inflammatory
mediator (very high) in severe
COVID-19
inflammatory cell activation
(very high) in severe COVID-19
inflammtory cell mediated
cytotoxicity (very high)in
severe COVID-19
increasing ferritin concentration
in blood (very high) in severe
COVID-19
increasing angiopoietin-2
concentration in blood (very
high) in severe COVID-19
inflammatory response in intestinal
in severe COVID-19
inflammatory response in blood
vessels (very high) in severe
COVID-19
multisystem inflammatory syndrome
in children
high fever
fibrosis in severe COVID-19
pyroptosis (very high)in severe
COVID-19
NACHT, LRR and PYD domains-containing
protein 3 (human)
apoptosis-associated speck-like
protein containing a CARD
(human)
release of DAMP molecules
by cell rupture (very high)
in severe COVID-19
binding of pattern recognition
receptor to DAMPs in severe
COVID-19
DAMP-triggered pattern recognition
receptor signaling in severe
COVID-19
inflammatory cell chemotaxis
(very high)in severe COVID-19
monocyte chemotaxis (very
high) in severe COVID-19
neutrophil chemotaxis (severe)
in severe COVID-19
natural killer cell chemotaxis
(very high) in severe COVID-19
monocyte activation involved
in inflammatory response (very
high) in severe COVID-19
inflammatory macrophage differentiation
(very high) in severe COVID-19
histamine secretion involved
in inflammatory response (very
high) in severe COVID-19
increasing vascular lumen
area in severe COVID-19
respiratory burst involved
in inflammatory response in
severe COVID-19
prostaglandin secretion involved
in inflammatory response in
severe COVID-19
response to pain sensation
stimulus in severe COVID-19
leukotriene secretion involved
in inflammatory response (very
high) in severe COVID-19
bradykinin secretion involved
in inflammatory response (very
high) in severe COVID-19
platelet activating factor
production involved in inflammatory
response (very high)
[COVID-198severe)]2
release of inflammatory mediator
from tissue-resident immune
cells (very high) in severe
COVID-19
leaking fluid from blood vessel
(very high) in severe COVID-19
inflammatory cytokine signaling
in severe COVID-19
additional macrophage activation
involved in inflammatory response
(vey high) in severe COVID-19
IL-1beta production (very
high) in severe COVID-19
multi-organ dysfunction in
severe COVID-19
neutrophil mediated cytotoxicity
(very high) in severe COVID-19
leaking content from cell
in severe COVID-19
increasing blood AST concentration
(very high) in severe COVID-19
increasing creatine kinase
concentration in severe COVID-19
secretion of lysosomal enzymes
involved in inflammatory response
(very high) in severe COVID-19
chemokine signaling (very
high) in severe COVID-19
inflammatory macrophage interleukin-8
production in severe COVID-19
chemokine (C-C motif) ligand
3 production (very high) in
severe COVID-19
CCL2 production (very high)
in severe COVID-19
CXCL8 signaling (very high)
in severe COVID-19
CCL3 signaling in severe COVID-19
CXCL10 signaling in severe
COVID-19
macrophage activation involved
in inflammatory response (vey
high) in severe COVID-19
inflammatory macrophage mediated
cytotoxicity (very high) in
severe COVID-19
Negative regulation of insulin
receptor signaling in severe
COVID-19
phagocytosis by inflammatory
macrophage in severe COVID-19
phagocytosis by neutrophils
in severe COVID-19
G-CSF production (very high)
in severe COVID-19
neutrophil phagocytosis insufficiency
in severe COVID-19
increasing D-dimer concentration
(very high) in severe COVID-19
platelet degranulation (very
high) in severe COVID-19
positive regulation of platelet
aggregation (very high) in
severe COVID-19
platelet morphology change
in severe COVID-19
fibrinogen binding (very high)
in severe COVID-19
blood coagulation, fibrin
clot formation (severe)in
severe COVID-19
thrombin-activated receptor
signaling (very high) in
severe COVID-19
platelet adhesion to basement
membrane (very high) in severe
COVID-19
D-dimer(human)in severe COVID-19
microvascular dysfunction
in severe COVID-19
Decreasing coagulation factor
level in severe COVID-19
arterial blood vessel
reactive oxygen species
smooth muscle contraction
(very high) in severe COVID-19
antiviral innate immune response
(very high) in severe COVID-19
viral entry-innate immune
response imbalance in severe
COVID-19
early infected cell destruction
(very high) in severe COVID-19
pattern recognition receptor
signaling in response to
virus in severe COVID-19
production of molecular mediator
of innate immune response
in severe COVID-19
dysregulation of immune response
in severe COVID-19
increasing blood flow in severe
COVID-19
increasing temperature (severe)in
severe COVID-19
edema
increasing peripheral vascular
resistance in severe COVID-19
delayed immunoglobulin production
in severe COVID-19
delayed immunoglobulin mediated
immune response in severe
COVID-19
positive regulation of fever
generation (very high) in
severe COVID-19
high fever in severe COVID-19
additional inflammatory cytokine
production (very high) in
severe COVID-19
transcription factor p65 (human)
positive regulation of interferon-alpha
production in the early stage
(low) in severe COVID-19
early type I interferon production
(low) in severe COVID-19
early interferon-alpha production
(low) in severe COVID-19
early interferon-beta production
(severe)
[COVID-19 (low)]2
early type I interferon signaling
(low) in severe COVID-19
negative regulation of early
IFN-responsive gene expression
in severe COVID-19
early cellular response to
type I interferon (low) in
severe COVID-19
IL-6 signaling (very high)
in severe COVID-19
HIF1A stabilization (very
high) in severe COVID-19
JNK signaling (very high)
in severe COVID-19
Insulin resistance (process)
in severe COVID-19
T cell mediated cytotoxicity
(very high) in severe COVID-19
T cell apoptotic process (very
high) in severe COVID-19
phagocytosis by inflammatory
macrophage (very high) in
severe COVID-19
blood
viral protein production (very
high) in severe COVID-19
viral genome replication (very
high) in severe COVID-19
viral entry into host cell
via vesicle-transport (very
high) in severe COVID-19
direct viral entry into host
cell via cell surface membrane
fusion (very high) in severe
COVID-19
virion assembly (very high)
in severe COVID-19
viral capsid assembly (very
high) in severe COVID-19
transport of virus (very high)
in severe COVID-19
SARS-CoV-2 shedding (very
high) in severe COVID-19
IgA antibody production in
severe COVID-19
neutrophil mediated cytotoxicity
to adjacent infected cells
in severe COVID-19
delayed type IgG antibody
production in severe COVID-19
antibody-dependent cellular
cytotoxicity (very high) in
severe COVID-19
adaptive immune response in
severe COVID-19
negative regulation of viral
action (very low) in severe
COVID-19
nitric oxide
subgenomic negative stranded
viral mRNA viral translation
(very high) in severe COVID-19
viral protein processing (very
high) in severe COVID-19
next generation of positive
stranded viral mRNA replication
(very high) in severe COVID-19
transport of virus in host
(cell to cell) (very high)
in severe COVID-19
transport of virus into central
nervous system (very high)
in severe COVID-19
positive stranded viral RNA
replication (very high) in
severe COVID-19
translation for viral replication
complex (very high) in severe
COVID-19
viral gene expression (very
high) in severe COVID-19
viral RNA replicase translation
(very high) in severe COVID-19
viral polyprotein processing
(very high) in severe COVID-19
uncoating of virus (very high)
in severe COVID-19
receptor-mediated endocytosis
of virus by host cell (very
high) in severe COVID-19
fusion of virus membrane with
host endosome membrane (very
high)in severe COVID-19
changing viral spike S2 protein
structure 2 (very high) in
severe COVID-19
cleavage of viral spike S2
protein (very high) in severe
COVID-19
fusion of virus membrane with
host plasma membrane (very
high) in severe COVID-19
host cell surface binding
(very high) in severe COVID-19
cleavage of viral spike S
protein (very high) in severe
COVID-19
changing viral spike S2 protein
structure (very high) in severe
COVID-19
fusion peptide insert into
host cell memnrane (very high)
in severe COVID-19
Metabolic Reprogramming (very
high) in severe COVID-19
glycolytic process in severe
COVID-19
Malfunctioning of TCA cycle
(very high) in severe COVID-19
Negative regulation of respiratory
complex proteins synthesis
(very high) in severe COVID-19
reverse electron transport
(very high) in severe COVID-19
virion attachment to host
cell (very high) in severe
COVID-19
entry receptor-mediated virion
attachment to host cell (very
high) in severe COVID-19
virion binding with host cell
surface receptor (very high)
in severe COVID-19
kallikrein signaling(very
high) in severe COVID-19
positive regulation of apoptotic
process in severe COVID-19
expression of ACE2 (very high)
in severe COVID-19
renin-angiotensin activation
in severe COVID-19
Systemic inflammatory response
in severe COVID-19
tissue factor production (very
high) in severe COVID-19
STAT3 signaling in severe
COVID-19
increasing fibrinogen concentration
(very high) in severe COVID-19
increasing blood glucose level
in severe COVID-19
positive regulation of IFN
alpha gene expression in severe
COVID-19
positive regulation of TNFΑ
gene expression (very high)in
severe COVID-19
positive regulation of IL1B
gene expression (severe)in
severe COVID-19
positive regulation of IL-6
gene expression (very high)
in severe COVID-19
positive regulation of IFNB1
gene expression (severe)in
severe COVID-19
glucose
symbiotic imbalance between
host and virus in severe COVID-19
viral proliferation (very
high) in severe COVID-19
infected cell damage (very
high) in severe COVID-19
complement-dependent cytotoxicity
(very high) in severe COVID-19
cytoplasmic pattern recognition
receptor signaling in response
to virus in severe COVID-19
decreasing number of virus
in severe COVID-19
STAT3 signal transduction
pathway
NfkB signaling in severe COVID-19
signal transducer and activator
of transcription 3 (human)
natural killer cell-mediated
apoptotic process of infected
cells in severe COVID-19
natural killer cell degranulation
in severe COVID-19
Release of IL6-R alpha from
cell surface in severe COVID-19
Increasing soluble IL-6R alpha
level in severe COVID-19
interleukin-6 receptor subunit
alpha (human)
septic shock (process) in
severe COVID-19
decreasing blood pressure
in severe COVID-19
septic shock
low blood pressure
positive regulation of glycolytic
process in severe COVID-19
T cell malfunction in severe
COVID-19
positive regulation of positive
stranded viral RNA replication
in severe COVID-19
negative regulation of T cell
mediated cytotoxicity in severe
COVID-19
HIF1A activation in severe
COVID-19
Expression of SLC2A1 (very
high) in severe COVID-19
solute carrier family 2, facilitated
glucose transporter member
1 (human)
positive regulation of PKM
gene expression (very high)
in severe COVID-19
positive regulation of PFKFB3
gene expression (very high)
in severe COVID-19
positive regulation of LDHA
gene expression (very high)
in severe COVID-19
Positive regulation of SLC2A1
gene expression (severe)in
severe COVID-19
Expression of LDHA (severe)in
severe COVID-19
Expression of PFKFB3 (very
high) in severe COVID-19
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
3 (human)
Expression of PKM (very high)
in severe COVID-19
pyruvate kinase PKM (human)
decreasing T cells in severe
COVID-19
succinate
natural killer cell activation
(very high) in severe COVID-19
T cell anergy in severe COVID-19
decreasing number of T cell
repertoires in severe COVID-19
heparin
infliximab
fibrinogen complex (human)
angiopoietin-2 (human)
Type III interferon signaling
in severe COVID-19
enteritis
natural killer cell mediated
cytotoxicity (very high) in
severe COVID-19
IL1 signaling (very high)
in severe COVID-19
CCL2 signaling in severe COVID-19
creatine kinase (human)
cytokine storm in COVID-19
associated with ARDS
pulmonary fibrosis in COVID-19
associated with ARDS
Tissue damage in lung (severe)in
COVID-19 associated with ARDS
respiratory dysfunction in
COVID-19 associated with ARDS
decreasing oxygen concentration
in blood in COVID-19 associated
with ARDS
shortness of breath
pulmonary hyaline membrane
formationin COVID-19 associated
with ARDS
Ground-glass opacification
on pulmonary HRCT
[Pulmonary
Pathological findings]
pulmonary hyaline membrane
fibrosis in COVID-19 associated
with ARDS
myoblast differentiation in
COVID-19 associated with ARDS
type I alveolar epithelial
cell injury in COVID-19 associated
with ARDS
leaking fluid to alveolar
space in COVID-19 associated
with ARDS
Type II alveolar epithelium
cell proliferation in COVID-19
associated with ARDS
epithelium damage in lung
in COVID-19 associated with
ARDS
pulmonary alveolar edema in
COVID-19 associated with ARDS
leaking fluid to pulmonary
interstitium in COVID-19 associated
with ARDS
pulmonary interstitium edema
in COVID-19 associated with
ARDS
inflammatory cell infiltration
to pulmonary interstitium
(very high) in COVID-19 associated
with ARDS
increasing lung weight in
COVID-19 associated with ARDS
cell death in lung (very high)
in COVID-19 associated with
ARDS
pulmonary cell necrosis in
COVID-19 associated with ARDS
thrombus formation in deep
vein in COVID-19 associated
with ARDS
detaching of blood clot in
COVID-19 associated with ARDS
neutrophil extracellular trap
formation in lung in COVID-19
associated with ARDS
positive regulation of blood
coagulation in lung (very
high) in COVID-19 associated
with ARDS
endothelium damage in lung
in COVID-19 associated with
ARDS
netosis in lung in COVID-19
associated with ARDS
blood coagulation in lung
(very high)in COVID-19 associated
with ARDS
inflammatory cell extravasation
[COVOD-19 with ARDS]
neutrophil extravasation in
lung (very high) in COVID-19
associated with ARDS
monocyte extravasation (very
high) in COVID-19 associated
with ARDS
negative regulation of blood
anticoagulantion in COVID-19
associated with ARDS
TNF signaling (very high)
in COVID-19 associated with
ARDS
Microthrombus formation in
lung in COVID-19 associated
with ARDS
expanding inflammation in
lung in COVID-19 associated
with ARDS
vascular endothelial cell
damage in lung (very high)
in COVID-19 associated with
ARDS
endothelial necrosis in lung
in COVID-19 associated with
ARDS
extracellular matrix excess
deposition in COVID-19 associated
with ARDS
myofibroblast cell
decreasing stem cell in COVID-19
associated with ARDS
transforming growth factor
beta-1 (human)
negative regulation of tissue
regeneration in COVID-19 associated
with ARDS
stem cell
oxygen molecular entity
embolus formation in lung
in COVID-19 associated with
ARDS
pulmonary artery narrowing
in COVID-19 associated with
ARDS
pulmonary ischemia in COVID-19
associated with ARDS
decreasing pulmonary blood
flow in COVID-19 associated
with ARDS
increasing blood pressure
in lung in COVID-19 associated
with ARDS
pulmonary artery
bleeding in lung in COVID-19
associated with ARDS
pulmonary infiltrates in COVID-19
associated with ARDS
hypoxia (very high) in COVID-19
associated with ARDS
negative regulation of platelet
maturation in COVID-19 associated
with ARDS
Increasing VEGF level (very
high) in COVID-19 associated
with ARDS
lung damage in COVID-19 associated
with ARDS
pulmonary alveoli damage in
COVID-19 associated with ARDS
respiratory system blood vessel
smooth muscle damage in COVID-19
associated with ARDS
blood vessel damage in lung
in COVID-19 associated with
ARDS
acute respiratory distress
syndrome
pus
neutrophile proliferation
(very high) in COVID-19 associated
with ARDS
decrease in platelet count
in COVID-19 associated with
ARDS
endothelium malfunction in
lung in COVID-19 associated
with ARDS
pulmonary blood vessel dysfunction
in COVID-19 associated with
ARDS
stroke
sprouting angiogenesis in
COVID-19 associated with ARDS
loss of vessel barrier integrity
in lung in COVID-19 associated
with ARDS
inflammatory cell infiltration
into lung (very high) in
COVID-19 associated with ARDS
vessel edema in lung in COVID-19
associated with ARDS
moving blood clot in COVID-19
associated with ARDS
platelet aggregation (very
high) in COVID-19 associated
with ARDS
positive regulation of thrombus
formation in lung in COVID-19
associated with ARDS
Negative regulation of nitric
oxide synthase activation
in COVID-19 associated with
ARDS
increasing vascular permeabilization
in lung (very high) in COVID-19
associated with ARDS
macrophage chemotaxis (very
high)in COVID-19 associated
with ARDS
Decreasing NO level in COVID-19
associated with ARDS
Negative regulation of response
to nitric oxide in COVID-19
associated with ARDS
positive regulation of complement
component gene expression
in COVID-19 associated with
ARDS
mannose-binding protein C
(human)
macrophage proliferation in
COVID-19 associated with ARDS
endothelium inflammatory response
in lung in COVID-19 associated
with ARDS
dysregulation of matrix metalloproteinase
secretion in endothelium in
COVID-19 associated with ARDS
Inflammatory cytokine production
(very high)in COVID-19 associated
with ARDS
endotheliitis
positive regulation of cell
adhesion molecule expression
(very high) in COVID-19 associated
with ARDS
cell adhesion molecule expression
(very high) in COVID-19 associated
with ARDS
tumor necrosis factor production
(very high) in COVID-19 associated
with ARDS
interferon-gamma production
(severe)in COVID-19 associated
with ARDS
neutrophil activation involved
in inflammatory response (very
high) in COVID-19 associated
with ARDS
right ventricular dysfunction
in COVID-19 associated with
ARDS
right ventricular damage in
COVID-19 associated with ARDS
acute cor pulmonale
vasoconstriction in lung in
COVID-19 associated with ARDS
angiotensin signaling in COVID-19
associated with ARDS
positive regulation of inflammatory
response in lung (very high)
in COVID-19 associated with
ARDS
Angiotensin II accumulation
(very high) in COVID-19 associated
with ARDS
negative regulation of Angiotensin
II hydrolysis (very high)
in COVID-19 associated with
ARDS
SARS-CoV-2 S binding to human
ACE2 (very high) in lung
in COVID-19 with ARDS
negative regulation of ACE2
activation in lung (very high)
in COVID-19 assiciated with
ARDS
SARS-CoV-2 entry to host cell
(very high) in COVID-19 associated
with ARDS
negative regulation of bradykinin
inactivation (very high)
in COVID-19 associated with
ARDS
reactive oxygen species biosynthetic
process in lung (very high)
in COVID-19 associated with
ARDS
chemokine production (very
high) in COVID-19 associated
with ARDS
thrombus formation in lung
(very high) in COVID-19 associated
with ARDS
lung malfunction in COVID-19
associated with ARDS
complement activation, classical
pathway (very high) in COVID-19
associated with ARDS
positive regulation of cell
adhesion in COVID-19 associated
with ARDS
complement activation, lectin
pathway (very high)in COVID-19
associated with ARDS
inflammatory response in lung
(very high) in COVID-19 associated
with ARDS
mannan-binding lectin serine
protease 2 (human)
complement activation (very
high) in COVID-19 associated
with ARDS
viral protein-host complement
activation protein binding
in COVID-19 associated with
ARDS
negative regulation of vasodilation
in COVID-19 associated with
ARDS
left ventricular dysfunction
in COVID-19 associated with
ARDS
decreasing cardiac output
in COVID-19 associated with
ARDS
pulmonary congestion in COVID-19
associated with ARDS
innate immune response in
lung (very high)in COVID-19
associated with ARDS
granulocyte
interleukin-6 production (very
high) in COVID-19 associated
with ARDS
positive regulation of innate
immune response in COVID-19
associated with ARDS
establishment of virus infection
in COVID-19 associated with
ARDS
pulmonary edema in COVID-19
associated with ARDS
pneumonia (disease)
pneumonia
cytotoxic T cell
membrane attack complex
T-helper 2 cell
interleukin-10 (human)
granzyme-mediated apoptotic
signaling pathway
natural killer cell
spike glycoprotein (SARS-CoV-2)
protein 3b (SARS-CoV-2)
host translation inhibitor
nsp1 (SARS-CoV-2)
host translation inhibitor
nsp1 (SARS-CoV-2)
T-helper 2 cell
T-helper 1 cell
interferon gamma (human)
inflammatory macrophage
macrophage
macrophage
neutrophil
macrophage
neutrophil
2'-5'-oligoadenylate synthase
1 (human)
interferon regulatory factor
3 (human)
interferon regulatory factor
3 (human)
serine/threonine-protein kinase
TBK1 (human)
serine/threonine-protein kinase
TBK1 (human)
serine/threonine-protein kinase
TBK1 (human)
non-structural protein 3 (SARS-CoV-2)
non-structural protein 3 (SARS-CoV-2)
interferon regulatory factor
3 (human)
interferon beta (human)
non-structural protein 3 (SARS-CoV-2)
T-helper 1 cell
interleukin-2 (human)
interleukin-2 (human)
inflammatory macrophage
interferon gamma (human)
macrophage
macrophage
Betacoronavirus
Betacoronavirus
replicase polyprotein 1a (SARS-CoV-2)
replicase polyprotein 1ab
(SARS-CoV-2)
non-structural protein 3 (SARS-CoV-2)
Betacoronavirus
Betacoronavirus
spike protein S2 (Betacoronavirus)
spike protein S2 (Betacoronavirus)
Betacoronavirus
spike glycoprotein (Betacoronacirus)
neuropilin-1 (human)
Betacoronavirus
SARS-CoV-2
macrophage
macrophage
inflammatory cell
neutrophil
neutrophil
neutrophil
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine
caspase-1 (human)
natural killer cell
natural killer cell
granzyme-mediated apoptotic
signaling pathway
natural killer cell
interleukin-1 beta (human)
interleukin-6 (human)
interleukin-6 (human)
T-helper 17 cell
interleukin-17A (human)
monocyte
monocyte
macrophage
bradykinin
SARS-CoV-2
SARS-CoV-2
SARS-CoV-2
cathepsin L1 (human)
viral RNA-directed RNA polymerase
complex
viral RNA-directed RNA polymerase
complex
replicase polyprotein 1a (SARS-CoV-2)
replicase polyprotein 1ab
(SARS-CoV-2)
SARS-CoV-2
SARS-CoV-2
spike protein S2 (SARS-CoV-2)
spike protein S2 (SARS-CoV-2)
cathepsin B (human)
cathepsin B (human)
spike protein S2 (SARS-CoV-2)
spike protein S2 (SARS-CoV-2)
spike protein S1 (SARS-CoV-2)
angiotensin-converting enzyme
2 (human)
spike glycoprotein (SARS-CoV-2)
spike glycoprotein (SARS-CoV-2)
spike protein S1 (SARS-CoV-2)
angiotensin-converting enzyme
2 (human)
angiotensin-converting enzyme
2 (human)
angiotensin-converting enzyme
2 (human)
inflammatory macrophage
inflammatory macrophage
inflammatory macrophage
inflammatory macrophage
inflammatory macrophage
transcription factor p65 (human)
interleukin-8 (human)
interleukin-8 (human)
C-X-C motif chemokine 10 (human)
platelet
platelet
tumor necrosis factor (human)
SARS-CoV-2
interleukin-1 beta (human)
hypoxia-inducible factor 1-alpha
(human)
interleukin-6 (human)
interleukin-6 (human)
neutrophil
neutrophil
neutrophil
neutrophil
type I interferon signaling
pathway
interferon regulatory factor
3 (human)
serine/threonine-protein kinase
TBK1 (human)
interferon beta (human)
interferon alpha (human)
pattern recognition receptor
signaling pathway
gasdermin-D (human)
continuant
continuant
T cell
hypoxia-inducible factor 1-alpha
(human)
L-lactate dehydrogenase A
chain (human)
L-lactate dehydrogenase A
chain (human)
pyruvate kinase PKM (human)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
3 (human)
inflammatory macrophage
spike glycoprotein (SARS-CoV-2)
cathepsin L1 (human)
cathepsin L1 (human)
transmembrane protease serine
2 (human)
spike protein S2 (SARS-CoV-2)
spike protein S2 (SARS-CoV-2)
FURIN (human)
C-C motif chemokine 2 (human)
C-C motif chemokine 3 (human)
inflammatory cell
neutrophil
macrophage
T cell
natural killer cell
monocyte
neutrophil
swelling symptom
dendritic cell
monocyte
inflammatory macrophage
interleukin-1 beta (human)
tumor necrosis factor (human)
interleukin-6 (human)
E-selectin (human)
vascular cell adhesion protein
1 (human)
spike glycoprotein (Betacoronacirus)
spike glycoprotein (SARS-CoV-2)
Betacoronavirus
SARS-CoV-2
cathepsin L1 (human)
spike glycoprotein (SARS-CoV-2)
interleukin-8 (human)
C-C motif chemokine 3 (human)
C-C motif chemokine 2 (human)
P-selectin (human)
E-selectin (human)
heat
swelling symptom
Dolor
high fever
rash
Betacoronavirus
oxygen molecular entity
platelet
platelet
vascular endothelial growth
factor A (human)
myofibroblast cell
tumor necrosis factor (human)
tumor necrosis factor (human)
blood
edema
neutrophil
neutrophil
interleukin-1 beta (human)
blood clot
disintegrin and metalloproteinase
domain-containing protein
17 (human)
tumor necrosis factor (human)
neutrophil
neutrophil
mannan-binding lectin serine
protease 2 (human)
nucleoprotein (SARS-CoV-2)
nucleoprotein (SARS-CoV-2)
interleukin-6 (human)
interleukin-6 (human)
macrophage
macrophage
interferon gamma (human)
neutrophil
neutrophil
SARS-CoV-2
spike protein S1 (SARS-CoV-2)
angiotensin-converting enzyme
2 (human)
angiotensin-converting enzyme
2 (human)
angiotensin-converting enzyme
2 (human)
angiotensin-converting enzyme
2 (human)
bradykinin
edema
nitric oxide
nitric oxide