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resultdiseasehas resulthas resulthas resulthas resulthas parthas resulthas resulthas participanthas resulthas participanthas resulthas resulthas resulthas resulthas resulthas resulthas resulthas resulthas resulthas outputhas outputhas resulthas parthas resulthas resulthas outputhas participanthas participanthas resulthas participantdiseasehas participanthas resultsymptomhas resulthas resulthas resulthas resulthas resulthas parthas outputhas resulthas resulthas resulthas outputhas resulthas resulthas participanthas outputhas parthas parthas resulthas resulthas resulthas resulthas parthas resulthas resulthas resulthas participanthas participanthas resulthas participanthas participanthas parthas outputhas resulthas resulthas resulthas parthas resulthas resulthas parthas resulthas resulthas parthas resulthas resulthas resulthas participanthas resulthas resulthas outputhas participanthas resulthas participanthas resulthas parthas parthas resultdiseasehas resulthas resulthas resulthas resulthas resulthas resulthas resulthas parthas parthas parthas participanthas parthas resultdiseasesymptomhas parthas resulthas resulthas inputhas resulthas resulthas resulthas resulthas resulthas parthas parthas resulthas resulthas parthas resultsymptomhas parthas participanthas inputsymptomBetacoronavirusviral RNA-directed RNA polymerasecomplexearly infected cell destructionin coronavirus infectionnatural killer cellinterferon regulatory factor7 (human)toll-like receptor 3 signalingpathwayToll-like receptor 3 (human)natural killer cell-mediatedapoptotic process of infectedcells in coronavirus infectiontype I interferon signalingpathwayinterferon alpha/beta receptor1 (human)interferon alpha/beta receptor2 (human)B cellplasma cellCytotoxic T cell activationvia T cell receptor contactwith antigen bound to MHCmolecule on antigen presentingcell in coronavirus infectionplasmacytoid dendritic cellinterferon alpha (human)interferon beta (human)MAVS complex assembly in coronavirusinfectionMDA-5 signaling pathwayRIG-I signaling pathwayantiviral innate immune responsereceptor RIG-I (human)PKR signaling pathwaymitochondrial antiviral-signalingprotein (human)serine/threonine-protein kinaseTBK1 (human)interferon regulatory factor3 (human)tyrosine-protein kinase JAK1(human)STAT1 signal transductionpathwaysignal transducer and activatorof transcription 1-alpha/beta(human)interleukin-6-mediated signalingpathwayinterleukin-6 (human)tumor necrosis factor (human)macrophageinterferon gamma (human)interleukin-8 (human)neutrophilinterleukin-17-mediated signalingpathwayinterleukin-17A (human)negative regulation of T-helper1 cell activation in coronavirusinfectionT-helper 2 cellinterleukin-4(human)interleukin-5 (human)interleukin-10 (human)interleukin-13 (human)T-helper 17 cellnegative regulation of typeII interferon production incoronavirus infectionpositive regulation of cytotoxicT cell activation in coronavirusinfectionT-helper 1 cellinterleukin-2 (human)spike glycoprotein (Betacoronacirus)vesicleendosome membraneviral envelopemoleculecell surfacecathepsin L1 (human)cathepsin B (human)toll-like receptor 7 signalingpathwayToll-like receptor 7 (human)cytoplasmic pattern recognitionreceptor signaling pathwayin response to virusTLR signaling pathwaypattern recognition receptorsignaling pathwaytoll-like receptor 8 signalingpathwayToll-like receptor 8 (human)T cell mediated removing infectedcell in coronavirus infection2'-5'-oligoadenylate synthase1 (human)interferon-induced, double-strandedRNA-activated protein kinase(human)interferon-induced GTP-bindingprotein Mx1 (human)macrophage antigen presentationincoronavirus infectionE-selectin (human)granzyme-mediated apoptoticsignaling pathwayinflammatory cellmonocyteviral structural proteinproduction in coronavirusinfectionspike glycoprotein (SARS-CoV-2)envelope small membrane protein(SARS-CoV-2)membrane protein (SARS-CoV-2)nucleoprotein (SARS-CoV-2)spike protein S2 (Betacoronavirus)changing viral inflammation-anti-inflammationbalance in coronavirus infectioncytotoxic T cellCD4-positive helper T cellcytotoxic T cell degranulationin coronavirus infectionadaptive immune memory responsein coronavirus infectionmemory B cellmemory T cellinterleukin-7 (human)interleukin-15 (human)inflammatory macrophagemembrane attack complexblood coagulation pathwayplatelet activation in coronavirusinfectionplateletP-selectin (human)continuantrashheattissuebiological membraneblood vesseldendritic cellhistamineDolorbradykininProstaglandin E2prostaglandinfevermulticellular organismleukotriene B4leukotrieneswelling symptom2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholinenegative regulation of typeI interferon production inCOVID-19protein 3b (SARS-CoV-2)host translation inhibitornsp1 (SARS-CoV-2)replicase polyprotein 1a (SARS-CoV-2)replicase polyprotein 1ab(SARS-CoV-2)viral polyprotein 1a processingin COVID-19viral polyprotein1ab processingin COVID-19non-structural protein 3 (SARS-CoV-2)3C-like proteinase (SARS-CoV-2)RIG-I signaling in COVID-19MDA-5 signaling in COVID-19PKR signaling in COVID-19TLR3 signaling in COVID-19TBK1 activation in COVID-19natural killer cell mediatedimmunity in COVID-19natural killer cell-mediatedapoptotic process of infectedcells in COVID-19IRF7 activation in COVID-19type I interferon productionin COVID-19immunoglobulin-mediated neutralizationin COVID-19Fc-gamma receptor signalingin COVID-19removing infected cell inadaptive immunity in COVID-19helper T cell enhancementof adaptive immune responsin COVID-19B cell activation involvedin adaptive immune responsein COVID-19negative regulation of viralaction in COVID-19positive regulation of MHCclass I biosynthetic processin COVID-19antigen processing and presentationof exogenous peptide antigenvia MHC class I in COVID-19cytotoxic T cell apoptoticprocess in COVID-19cytotoxic T cell degranulationin COVID-19natural killer cell apoptoticprocessin COVID-19removing infected cell inCOVID-19early removing infected cellin COVID-19phagocytosis in COVID-19IRF3 activation in COVID-19JAK signaling in COVID-19STAT1 signaling in COVID-19negative regulation of viralgene expression in COVID-19negative regulation of viralgenome replication in COVID-19antigen processing and presentationof exogenous peptide antigenvia MHC class II in COVID-19T-helper cell differentiationin COVID-19phagocytosis by inflammatorymacrophage in COVID-19neutrophil mediated cytotoxicityin COVID-19T-helper 2 cell cytokine productionin COVID-19T-helper 2 cell differentiationin COVID-19T-helper 2 cell activationin COVID-19T-helper 1 cell cytokine productionin COVID-19IL-2 signaling in COVID-19spike protein S1 (SARS-CoV-2)neuropilin-1 (human)angiotensin-converting enzyme2 (human)spike protein S2 (SARS-CoV-2)spike protein S2\' (SARS-CoV-2)transmembrane protease serine2 (human)FURIN (human)SARS-CoV-21-phosphatidyl-1D-myo-inositol3,5-bisphosphatephosphoinositidecleavage of viral spike Sprotein 2 in COVID-19Plpro gene expression in COVID-19early infected cell destructionin COVID-19antigen presentationin COVID-19receiving viral signal inpattern recognition signalingpathway in COVID-19TLR7 signaling in COVID-19interferon-beta productionin COVID-19increasing interferon-betalevel in COVID-19interferon-alpha productionin COVID-19type I interferon signalingin COVID-19cellular response to typeI interferon in COVID-19negative regulation of viraltranslation in COVID-19TLR8 signaling in COVID-19cell damage recognition inCOVID-19cytolysis in COVID-19production of molecular mediatorof immune response in COVID-19positive regulation of viralRNA catabolic process in COVID-19negative regulation of viralentry into host cell in COVID-19negative regulation of virionattachment to host cell inCOVID-19TLR signaling in COVID-19increasing virus resitancein COVID-19T-helper 1 type immune responsein COVID-19T-helper 1 cell activationin COVID-19T-helper 1 cell differentiationin COVID-19cellular immune response inCOVID-19positive regulation of immunecell activation in COVID-19macrophage differentiationin COVID-19binding of pattern recognitionreceptor to PAMPs in COVID-19humoral immune response inCOVID-19T-helper 2 type immune responsein COVID-19inflammation-anti-inflammationimbalance in COVID-19B cell mediated immunity inCOVID-19activation of membrane attackcomplex in COVID-19phagocytosis by inflammatorymacrophagein COVID-19neutrophil clearance in COVID-19negative regulation of TBK1activation in COVID-19Negative regulation of typeI interferon signaling pathwayin COVID-19Negative regulation of TBK1phosphorylation in COVID-19suppression by virus of hosttranslation in COVID-19positive regulation of viralgenome replication in COVID-19negative regulation of typeIII interferon productionin COVID-19C-C motif chemokine 3 (human)C-C motif chemokine 2 (human)interleukin-1 beta (human)hypoxia-inducible factor 1-alpha(human)Negative regulation of ISG15modification by small proteinconjugation in COVID-19ubiquitin-like protein ISG15(human)Negative regulation of IRF3modification by small proteinconjugation in COVID-19Negative regulation of nucleartransport in COVID-19negative regulation of INFB1expression in COVID-19Negative regulation of ISG15gene expression in COVID-19Negative regulation of OAS1gene expression in COVID-19interferon-beta production(very low) in COVID-19negative regulation of inflammatoryresponse in COVID-19neutrophil apoptotic processin COVID-19anti-inflammatory cytokineproduction in COVID-19Negative regulation of EIF2AK2gene expression in COVID-19Negative regulation of MX1gene expression in COVID-19complementgranulocyte colony-stimulatingfactor (human)T cellGM-CSF production in COVID-19granulocyte-macrophage colony-stimulatingfactor (human)blood clottissue factor (human)C-reactive protein (human)ferritin complex (human)increasing lactate dehydrogenaseconcentration in COVID-19L-lactate dehydrogenase Achain (human)vascular endothelial growthfactor A (human)SARS-CoV-2 S binding to humanACE2 on nasal epitherialcell in COVID-19disturbances of sensationof smell and tasteopsonization in COVID-19complement activation, alternativepathway in COVID-19vascular cell adhesion protein1 (human)tumor necrosis factor-mediatedsignaling pathwaydisintegrin and metalloproteinasedomain-containing protein17 (human)angiotensin IIangiotensin-activated signalingpathwaytype-1 angiotensin II receptor(human)release of anaphylatoxin inCOVID-19positive regulation of phagocytosisin COVID-19IL-1 signal transduction pathwaythrombin-activated receptorsignaling pathwaycollagenchemokine (C-C motif) ligand2 signaling pathwayinterleukin-2-mediated signalingpathwayplasma kallikrein-kinin cascadeplasma kallikrein (human)chemokine (C-C motif) ligand3 signaling pathwaychemokine (C-X-C motif) ligand10 signaling pathwayC-X-C motif chemokine 10 (human)type III interferon signalingpathwaychemokine (C-C motif) ligand10 production in COVID-19chemokine-mediated signalingpathwaychemokine (C-X-C motif) ligand8 signaling pathwaytissue-resident macrophageinflammatory cytokine-mediatedsignaling pathwaytwo pore calcium channel protein2 (human)1-phosphatidylinositol 3-phosphate5-kinase (human)platelet activating factorbiosynthetic process (veryhigh) in severe COVID-19platelet activation (veryhigh) in severe COVID-19fibrinolysis (very low) insevere COVID-19negative regulation of fibrinolysisinsevere COVID-19viral replication complexformation and maintenance(very high) in severe COVID-19_2subgenomic negative strandedviral mRNA biosynthetic process(veryhigh) in severe COVID-19full length negative strandedviral mRNA biosynthetic process(very high) in severe COVID-19IL-1beta processing in severeCOVID-19caspase-1 (human)mitochondrial dysfunction(very high) in severe COVID-19release of DNA from mitochondriain severe COVID-19mitochondrial DNAIL-17 signaling in severeCOVID-19autoimmune responsein severeCOVID-19T-helper 17 cell differentiationin severe COVID-19T-helper 17 cell cytokineproduction in severe COVID-19positive regulation of HIF1Agene expression (very high)in severe COVID-19Expression of HIF1A (veryhigh) in severe COVID-19increasing blood CRP concentration(very high) in severe COVID-19increasing oxidative stress(very high)in severe COVID-19cellular damage (very high)in severe COVID-19negative regulation of inflammatoryresponse (very low) in severeCOVID-19neutrophil apoptotic process(low) in severe COVID-19neutrophil clearance (low)in severe COVID-19tissue regeneration (veryhigh) in severe COVID-19anti-inflammatory cytokineproduction (low) in severeCOVID-19inflammation-anti-inflammationimbalance in severe COVID-19apoptotic cell clearance (low)in severe COVID-19apoptotic process (very high)in severe COVID-19cell damage recognition insevere COVID-19T cell exhaustion (very high)in severe COVID-19negative regulation of T cellmediated immunity (very high)in severe COVID-19Negative regulation of T cellproliferation (very high)in severe COVID-19programmed cell death protein1 (human)pore formation in membraneof other organismin severeCOVID-19gasdermin-D (human)hypofunction of vasodilationin severe COVID-19hypofunction of mitochondrialfatty acid beta-oxidationin severe COVID-19T cell activation (very high)in severe COVID-19natural killer cell cytokineproduction in severe COVID-19inflammasome activation (veryhigh) in severe COVID-19synthesis or release of inflammatorymediator (very high) in severeCOVID-19inflammatory cell activation(very high) in severe COVID-19inflammtory cell mediatedcytotoxicity (very high)insevere COVID-19increasing ferritin concentrationin blood (very high) in severeCOVID-19increasing angiopoietin-2concentration in blood (veryhigh) in severe COVID-19inflammatory response in intestinalin severe COVID-19inflammatory response in bloodvessels (very high) in severeCOVID-19multisystem inflammatory syndromein childrenhigh feverfibrosis in severe COVID-19pyroptosis (very high)in severeCOVID-19NACHT, LRR and PYD domains-containingprotein 3 (human)apoptosis-associated speck-likeprotein containing a CARD(human)release of DAMP moleculesby cell rupture (very high)in severe COVID-19binding of pattern recognitionreceptor to DAMPs in severeCOVID-19DAMP-triggered pattern recognitionreceptor signaling in severeCOVID-19inflammatory cell chemotaxis(very high)in severe COVID-19monocyte chemotaxis (veryhigh) in severe COVID-19neutrophil chemotaxis (severe)in severe COVID-19natural killer cell chemotaxis(very high) in severe COVID-19monocyte activation involvedin inflammatory response (veryhigh) in severe COVID-19inflammatory macrophage differentiation(very high) in severe COVID-19histamine secretion involvedin inflammatory response (veryhigh) in severe COVID-19increasing vascular lumenarea in severe COVID-19respiratory burst involvedin inflammatory response insevere COVID-19prostaglandin secretion involvedin inflammatory response insevere COVID-19response to pain sensationstimulus in severe COVID-19leukotriene secretion involvedin inflammatory response (veryhigh) in severe COVID-19bradykinin secretion involvedin inflammatory response (veryhigh) in severe COVID-19platelet activating factorproduction involved in inflammatoryresponse (very high) [COVID-198severe)]2release of inflammatory mediatorfrom tissue-resident immunecells (very high) in severeCOVID-19leaking fluid from blood vessel(very high) in severe COVID-19inflammatory cytokine signalingin severe COVID-19additional macrophage activationinvolved in inflammatory response(vey high) in severe COVID-19IL-1beta production (veryhigh) in severe COVID-19multi-organ dysfunction insevere COVID-19neutrophil mediated cytotoxicity(very high) in severe COVID-19leaking content from cellin severe COVID-19increasing blood AST concentration(very high) in severe COVID-19increasing creatine kinaseconcentration in severe COVID-19secretion of lysosomal enzymesinvolved in inflammatory response(very high) in severe COVID-19chemokine signaling (veryhigh) in severe COVID-19inflammatory macrophage interleukin-8production in severe COVID-19chemokine (C-C motif) ligand3 production (very high) insevere COVID-19CCL2 production (very high)in severe COVID-19CXCL8 signaling (very high)in severe COVID-19CCL3 signaling in severe COVID-19CXCL10 signaling in severeCOVID-19macrophage activation involvedin inflammatory response (veyhigh) in severe COVID-19inflammatory macrophage mediatedcytotoxicity (very high) insevere COVID-19Negative regulation of insulinreceptor signaling in severeCOVID-19phagocytosis by inflammatorymacrophage in severe COVID-19phagocytosis by neutrophilsin severe COVID-19G-CSF production (very high)in severe COVID-19neutrophil phagocytosis insufficiencyin severe COVID-19increasing D-dimer concentration(very high) in severe COVID-19platelet degranulation (veryhigh) in severe COVID-19positive regulation of plateletaggregation (very high) insevere COVID-19platelet morphology changein severe COVID-19fibrinogen binding (very high)in severe COVID-19blood coagulation, fibrinclot formation (severe)insevere COVID-19thrombin-activated receptorsignaling (very high) insevere COVID-19platelet adhesion to basementmembrane (very high) in severeCOVID-19D-dimer(human)in severe COVID-19microvascular dysfunctionin severe COVID-19Decreasing coagulation factorlevel in severe COVID-19arterial blood vesselreactive oxygen speciessmooth muscle contraction(very high) in severe COVID-19antiviral innate immune response(very high) in severe COVID-19viral entry-innate immuneresponse imbalance in severeCOVID-19early infected cell destruction(very high) in severe COVID-19pattern recognition receptorsignaling in response tovirus in severe COVID-19production of molecular mediatorof innate immune responsein severe COVID-19dysregulation of immune responsein severe COVID-19increasing blood flow in severeCOVID-19increasing temperature (severe)insevere COVID-19edemaincreasing peripheral vascularresistance in severe COVID-19delayed immunoglobulin productionin severe COVID-19delayed immunoglobulin mediatedimmune response in severeCOVID-19positive regulation of fevergeneration (very high) insevere COVID-19high fever in severe COVID-19additional inflammatory cytokineproduction (very high) insevere COVID-19transcription factor p65 (human)positive regulation of interferon-alphaproduction in the early stage(low) in severe COVID-19early type I interferon production(low) in severe COVID-19early interferon-alpha production(low) in severe COVID-19early interferon-beta production(severe) [COVID-19 (low)]2early type I interferon signaling(low) in severe COVID-19negative regulation of earlyIFN-responsive gene expressionin severe COVID-19early cellular response totype I interferon (low) insevere COVID-19IL-6 signaling (very high)in severe COVID-19HIF1A stabilization (veryhigh) in severe COVID-19JNK signaling (very high)in severe COVID-19Insulin resistance (process)in severe COVID-19T cell mediated cytotoxicity(very high) in severe COVID-19T cell apoptotic process (veryhigh) in severe COVID-19phagocytosis by inflammatorymacrophage (very high) insevere COVID-19bloodviral protein production (veryhigh) in severe COVID-19viral genome replication (veryhigh) in severe COVID-19viral entry into host cellvia vesicle-transport (veryhigh) in severe COVID-19direct viral entry into hostcell via cell surface membranefusion (very high) in severeCOVID-19virion assembly (very high)in severe COVID-19viral capsid assembly (veryhigh) in severe COVID-19transport of virus (very high)in severe COVID-19SARS-CoV-2 shedding (veryhigh) in severe COVID-19IgA antibody production insevere COVID-19neutrophil mediated cytotoxicityto adjacent infected cellsin severe COVID-19delayed type IgG antibodyproduction in severe COVID-19antibody-dependent cellularcytotoxicity (very high) insevere COVID-19adaptive immune response insevere COVID-19negative regulation of viralaction (very low) in severeCOVID-19nitric oxidesubgenomic negative strandedviral mRNA viral translation(very high) in severe COVID-19viral protein processing (veryhigh) in severe COVID-19next generation of positivestranded viral mRNA replication(very high) in severe COVID-19transport of virus in host(cell to cell) (very high)in severe COVID-19transport of virus into centralnervous system (very high)in severe COVID-19positive stranded viral RNAreplication (very high) insevere COVID-19translation for viral replicationcomplex (very high) in severeCOVID-19viral gene expression (veryhigh) in severe COVID-19viral RNA replicase translation(very high) in severe COVID-19viral polyprotein processing(very high) in severe COVID-19uncoating of virus (very high)in severe COVID-19receptor-mediated endocytosisof virus by host cell (veryhigh) in severe COVID-19fusion of virus membrane withhost endosome membrane (veryhigh)in severe COVID-19changing viral spike S2 proteinstructure 2 (very high) insevere COVID-19cleavage of viral spike S2protein (very high) in severeCOVID-19fusion of virus membrane withhost plasma membrane (veryhigh) in severe COVID-19host cell surface binding(very high) in severe COVID-19cleavage of viral spike Sprotein (very high) in severeCOVID-19changing viral spike S2 proteinstructure (very high) in severeCOVID-19fusion peptide insert intohost cell memnrane (very high)in severe COVID-19Metabolic Reprogramming (veryhigh) in severe COVID-19glycolytic process in severeCOVID-19Malfunctioning of TCA cycle(very high) in severe COVID-19Negative regulation of respiratorycomplex proteins synthesis(very high) in severe COVID-19reverse electron transport(very high) in severe COVID-19virion attachment to hostcell (very high) in severeCOVID-19entry receptor-mediated virionattachment to host cell (veryhigh) in severe COVID-19virion binding with host cellsurface receptor (very high)in severe COVID-19kallikrein signaling(veryhigh) in severe COVID-19positive regulation of apoptoticprocess in severe COVID-19expression of ACE2 (very high)in severe COVID-19renin-angiotensin activationin severe COVID-19Systemic inflammatory responsein severe COVID-19tissue factor production (veryhigh) in severe COVID-19STAT3 signaling in severeCOVID-19increasing fibrinogen concentration(very high) in severe COVID-19increasing blood glucose levelin severe COVID-19positive regulation of IFNalpha gene expression in severeCOVID-19positive regulation of TNFΑgene expression (very high)insevere COVID-19positive regulation of IL1Bgene expression (severe)insevere COVID-19positive regulation of IL-6gene expression (very high)in severe COVID-19positive regulation of IFNB1gene expression (severe)insevere COVID-19glucosesymbiotic imbalance betweenhost and virus in severe COVID-19viral proliferation (veryhigh) in severe COVID-19infected cell damage (veryhigh) in severe COVID-19complement-dependent cytotoxicity(very high) in severe COVID-19cytoplasmic pattern recognitionreceptor signaling in responseto virus in severe COVID-19decreasing number of virusin severe COVID-19STAT3 signal transductionpathwayNfkB signaling in severe COVID-19signal transducer and activatorof transcription 3 (human)natural killer cell-mediatedapoptotic process of infectedcells in severe COVID-19natural killer cell degranulationin severe COVID-19Release of IL6-R alpha fromcell surface in severe COVID-19Increasing soluble IL-6R alphalevel in severe COVID-19interleukin-6 receptor subunitalpha (human)septic shock (process) insevere COVID-19decreasing blood pressurein severe COVID-19septic shocklow blood pressurepositive regulation of glycolyticprocess in severe COVID-19T cell malfunction in severeCOVID-19positive regulation of positivestranded viral RNA replicationin severe COVID-19negative regulation of T cellmediated cytotoxicity in severeCOVID-19HIF1A activation in severeCOVID-19Expression of SLC2A1 (veryhigh) in severe COVID-19solute carrier family 2, facilitatedglucose transporter member1 (human)positive regulation of PKMgene expression (very high)in severe COVID-19positive regulation of PFKFB3gene expression (very high)in severe COVID-19positive regulation of LDHAgene expression (very high)in severe COVID-19Positive regulation of SLC2A1gene expression (severe)insevere COVID-19Expression of LDHA (severe)insevere COVID-19Expression of PFKFB3 (veryhigh) in severe COVID-196-phosphofructo-2-kinase/fructose-2,6-bisphosphatase3 (human)Expression of PKM (very high)in severe COVID-19pyruvate kinase PKM (human)decreasing T cells in severeCOVID-19succinatenatural killer cell activation(very high) in severe COVID-19T cell anergy in severe COVID-19decreasing number of T cellrepertoires in severe COVID-19heparininfliximabfibrinogen complex (human)angiopoietin-2 (human)Type III interferon signalingin severe COVID-19enteritisnatural killer cell mediatedcytotoxicity (very high) insevere COVID-19IL1 signaling (very high)in severe COVID-19CCL2 signaling in severe COVID-19creatine kinase (human)cytokine storm in COVID-19associated with ARDSpulmonary fibrosis in COVID-19associated with ARDSTissue damage in lung (severe)inCOVID-19 associated with ARDSrespiratory dysfunction inCOVID-19 associated with ARDSdecreasing oxygen concentrationin blood in COVID-19 associatedwith ARDSshortness of breathpulmonary hyaline membraneformationin COVID-19 associatedwith ARDSGround-glass opacificationon pulmonary HRCT [PulmonaryPathological findings]pulmonary hyaline membranefibrosis in COVID-19 associatedwith ARDSmyoblast differentiation inCOVID-19 associated with ARDStype I alveolar epithelialcell injury in COVID-19 associatedwith ARDSleaking fluid to alveolarspace in COVID-19 associatedwith ARDSType II alveolar epitheliumcell proliferation in COVID-19associated with ARDSepithelium damage in lungin COVID-19 associated withARDSpulmonary alveolar edema inCOVID-19 associated with ARDSleaking fluid to pulmonaryinterstitium in COVID-19 associatedwith ARDSpulmonary interstitium edemain COVID-19 associated withARDSinflammatory cell infiltrationto pulmonary interstitium(very high) in COVID-19 associatedwith ARDSincreasing lung weight inCOVID-19 associated with ARDScell death in lung (very high)in COVID-19 associated withARDSpulmonary cell necrosis inCOVID-19 associated with ARDSthrombus formation in deepvein in COVID-19 associatedwith ARDSdetaching of blood clot inCOVID-19 associated with ARDSneutrophil extracellular trapformation in lung in COVID-19associated with ARDSpositive regulation of bloodcoagulation in lung (veryhigh) in COVID-19 associatedwith ARDSendothelium damage in lungin COVID-19 associated withARDSnetosis in lung in COVID-19associated with ARDSblood coagulation in lung(very high)in COVID-19 associatedwith ARDSinflammatory cell extravasation[COVOD-19 with ARDS]neutrophil extravasation inlung (very high) in COVID-19associated with ARDSmonocyte extravasation (veryhigh) in COVID-19 associatedwith ARDSnegative regulation of bloodanticoagulantion in COVID-19associated with ARDSTNF signaling (very high)in COVID-19 associated withARDSMicrothrombus formation inlung in COVID-19 associatedwith ARDSexpanding inflammation inlung in COVID-19 associatedwith ARDSvascular endothelial celldamage in lung (very high)in COVID-19 associated withARDSendothelial necrosis in lungin COVID-19 associated withARDSextracellular matrix excessdeposition in COVID-19 associatedwith ARDSmyofibroblast celldecreasing stem cell in COVID-19associated with ARDStransforming growth factorbeta-1 (human)negative regulation of tissueregeneration in COVID-19 associatedwith ARDSstem celloxygen molecular entityembolus formation in lungin COVID-19 associated withARDSpulmonary artery narrowingin COVID-19 associated withARDSpulmonary ischemia in COVID-19associated with ARDSdecreasing pulmonary bloodflow in COVID-19 associatedwith ARDSincreasing blood pressurein lung in COVID-19 associatedwith ARDSpulmonary arterybleeding in lung in COVID-19associated with ARDSpulmonary infiltrates in COVID-19associated with ARDShypoxia (very high) in COVID-19associated with ARDSnegative regulation of plateletmaturation in COVID-19 associatedwith ARDSIncreasing VEGF level (veryhigh) in COVID-19 associatedwith ARDSlung damage in COVID-19 associatedwith ARDSpulmonary alveoli damage inCOVID-19 associated with ARDSrespiratory system blood vesselsmooth muscle damage in COVID-19associated with ARDSblood vessel damage in lungin COVID-19 associated withARDSacute respiratory distresssyndromepusneutrophile proliferation(very high) in COVID-19 associatedwith ARDSdecrease in platelet countin COVID-19 associated withARDSendothelium malfunction inlung in COVID-19 associatedwith ARDSpulmonary blood vessel dysfunctionin COVID-19 associated withARDSstrokesprouting angiogenesis inCOVID-19 associated with ARDSloss of vessel barrier integrityin lung in COVID-19 associatedwith ARDSinflammatory cell infiltrationinto lung (very high) inCOVID-19 associated with ARDSvessel edema in lung in COVID-19associated with ARDSmoving blood clot in COVID-19associated with ARDSplatelet aggregation (veryhigh) in COVID-19 associatedwith ARDSpositive regulation of thrombusformation in lung in COVID-19associated with ARDSNegative regulation of nitricoxide synthase activationin COVID-19 associated withARDSincreasing vascular permeabilizationin lung (very high) in COVID-19associated with ARDSmacrophage chemotaxis (veryhigh)in COVID-19 associatedwith ARDSDecreasing NO level in COVID-19associated with ARDSNegative regulation of responseto nitric oxide in COVID-19associated with ARDSpositive regulation of complementcomponent gene expressionin COVID-19 associated withARDSmannose-binding protein C(human)macrophage proliferation inCOVID-19 associated with ARDSendothelium inflammatory responsein lung in COVID-19 associatedwith ARDSdysregulation of matrix metalloproteinasesecretion in endothelium inCOVID-19 associated with ARDSInflammatory cytokine production(very high)in COVID-19 associatedwith ARDSendotheliitispositive regulation of celladhesion molecule expression(very high) in COVID-19 associatedwith ARDScell adhesion molecule expression(very high) in COVID-19 associatedwith ARDStumor necrosis factor production(very high) in COVID-19 associatedwith ARDSinterferon-gamma production(severe)in COVID-19 associatedwith ARDSneutrophil activation involvedin inflammatory response (veryhigh) in COVID-19 associatedwith ARDSright ventricular dysfunctionin COVID-19 associated withARDSright ventricular damage inCOVID-19 associated with ARDSacute cor pulmonalevasoconstriction in lung inCOVID-19 associated with ARDSangiotensin signaling in COVID-19associated with ARDSpositive regulation of inflammatoryresponse in lung (very high)in COVID-19 associated withARDSAngiotensin II accumulation(very high) in COVID-19 associatedwith ARDSnegative regulation of AngiotensinII hydrolysis (very high)in COVID-19 associated withARDSSARS-CoV-2 S binding to humanACE2 (very high) in lungin COVID-19 with ARDSnegative regulation of ACE2activation in lung (very high)in COVID-19 assiciated withARDSSARS-CoV-2 entry to host cell(very high) in COVID-19 associatedwith ARDSnegative regulation of bradykinininactivation (very high)in COVID-19 associated withARDSreactive oxygen species biosyntheticprocess in lung (very high)in COVID-19 associated withARDSchemokine production (veryhigh) in COVID-19 associatedwith ARDSthrombus formation in lung(very high) in COVID-19 associatedwith ARDSlung malfunction in COVID-19associated with ARDScomplement activation, classicalpathway (very high) in COVID-19associated with ARDSpositive regulation of celladhesion in COVID-19 associatedwith ARDScomplement activation, lectinpathway (very high)in COVID-19associated with ARDSinflammatory response in lung(very high) in COVID-19 associatedwith ARDSmannan-binding lectin serineprotease 2 (human)complement activation (veryhigh) in COVID-19 associatedwith ARDSviral protein-host complementactivation protein bindingin COVID-19 associated withARDSnegative regulation of vasodilationin COVID-19 associated withARDSleft ventricular dysfunctionin COVID-19 associated withARDSdecreasing cardiac outputin COVID-19 associated withARDSpulmonary congestion in COVID-19associated with ARDSinnate immune response inlung (very high)in COVID-19associated with ARDSgranulocyteinterleukin-6 production (veryhigh) in COVID-19 associatedwith ARDSpositive regulation of innateimmune response in COVID-19associated with ARDSestablishment of virus infectionin COVID-19 associated withARDSpulmonary edema in COVID-19associated with ARDSpneumonia (disease)pneumoniacytotoxic T cellmembrane attack complexT-helper 2 cellinterleukin-10 (human)granzyme-mediated apoptoticsignaling pathwaynatural killer cellspike glycoprotein (SARS-CoV-2)protein 3b (SARS-CoV-2)host translation inhibitornsp1 (SARS-CoV-2)host translation inhibitornsp1 (SARS-CoV-2)T-helper 2 cellT-helper 1 cellinterferon gamma (human)inflammatory macrophagemacrophagemacrophageneutrophilmacrophageneutrophil2'-5'-oligoadenylate synthase1 (human)interferon regulatory factor3 (human)interferon regulatory factor3 (human)serine/threonine-protein kinaseTBK1 (human)serine/threonine-protein kinaseTBK1 (human)serine/threonine-protein kinaseTBK1 (human)non-structural protein 3 (SARS-CoV-2)non-structural protein 3 (SARS-CoV-2)interferon regulatory factor3 (human)interferon beta (human)non-structural protein 3 (SARS-CoV-2)T-helper 1 cellinterleukin-2 (human)interleukin-2 (human)inflammatory macrophageinterferon gamma (human)macrophagemacrophageBetacoronavirusBetacoronavirusreplicase polyprotein 1a (SARS-CoV-2)replicase polyprotein 1ab(SARS-CoV-2)non-structural protein 3 (SARS-CoV-2)BetacoronavirusBetacoronavirusspike protein S2 (Betacoronavirus)spike protein S2 (Betacoronavirus)Betacoronavirusspike glycoprotein (Betacoronacirus)neuropilin-1 (human)BetacoronavirusSARS-CoV-2macrophagemacrophageinflammatory cellneutrophilneutrophilneutrophil2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholinecaspase-1 (human)natural killer cellnatural killer cellgranzyme-mediated apoptoticsignaling pathwaynatural killer cellinterleukin-1 beta (human)interleukin-6 (human)interleukin-6 (human)T-helper 17 cellinterleukin-17A (human)monocytemonocytemacrophagebradykininSARS-CoV-2SARS-CoV-2SARS-CoV-2cathepsin L1 (human)viral RNA-directed RNA polymerasecomplexviral RNA-directed RNA polymerasecomplexreplicase polyprotein 1a (SARS-CoV-2)replicase polyprotein 1ab(SARS-CoV-2)SARS-CoV-2SARS-CoV-2spike protein S2 (SARS-CoV-2)spike protein S2 (SARS-CoV-2)cathepsin B (human)cathepsin B (human)spike protein S2 (SARS-CoV-2)spike protein S2 (SARS-CoV-2)spike protein S1 (SARS-CoV-2)angiotensin-converting enzyme2 (human)spike glycoprotein (SARS-CoV-2)spike glycoprotein (SARS-CoV-2)spike protein S1 (SARS-CoV-2)angiotensin-converting enzyme2 (human)angiotensin-converting enzyme2 (human)angiotensin-converting enzyme2 (human)inflammatory macrophageinflammatory macrophageinflammatory macrophageinflammatory macrophageinflammatory macrophagetranscription factor p65 (human)interleukin-8 (human)interleukin-8 (human)C-X-C motif chemokine 10 (human)plateletplatelettumor necrosis factor (human)SARS-CoV-2interleukin-1 beta (human)hypoxia-inducible factor 1-alpha(human)interleukin-6 (human)interleukin-6 (human)neutrophilneutrophilneutrophilneutrophiltype I interferon signalingpathwayinterferon regulatory factor3 (human)serine/threonine-protein kinaseTBK1 (human)interferon beta (human)interferon alpha (human)pattern recognition receptorsignaling pathwaygasdermin-D (human)continuantcontinuantT cellhypoxia-inducible factor 1-alpha(human)L-lactate dehydrogenase Achain (human)L-lactate dehydrogenase Achain (human)pyruvate kinase PKM (human)6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase3 (human)inflammatory macrophagespike glycoprotein (SARS-CoV-2)cathepsin L1 (human)cathepsin L1 (human)transmembrane protease serine2 (human)spike protein S2 (SARS-CoV-2)spike protein S2 (SARS-CoV-2)FURIN (human)C-C motif chemokine 2 (human)C-C motif chemokine 3 (human)inflammatory cellneutrophilmacrophageT cellnatural killer cellmonocyteneutrophilswelling symptomdendritic cellmonocyteinflammatory macrophageinterleukin-1 beta (human)tumor necrosis factor (human)interleukin-6 (human)E-selectin (human)vascular cell adhesion protein1 (human)spike glycoprotein (Betacoronacirus)spike glycoprotein (SARS-CoV-2)BetacoronavirusSARS-CoV-2cathepsin L1 (human)spike glycoprotein (SARS-CoV-2)interleukin-8 (human)C-C motif chemokine 3 (human)C-C motif chemokine 2 (human)P-selectin (human)E-selectin (human)heatswelling symptomDolorhigh feverrashBetacoronavirusoxygen molecular entityplateletplateletvascular endothelial growthfactor A (human)myofibroblast celltumor necrosis factor (human)tumor necrosis factor (human)bloodedemaneutrophilneutrophilinterleukin-1 beta (human)blood clotdisintegrin and metalloproteinasedomain-containing protein17 (human)tumor necrosis factor (human)neutrophilneutrophilmannan-binding lectin serineprotease 2 (human)nucleoprotein (SARS-CoV-2)nucleoprotein (SARS-CoV-2)interleukin-6 (human)interleukin-6 (human)macrophagemacrophageinterferon gamma (human)neutrophilneutrophilSARS-CoV-2spike protein S1 (SARS-CoV-2)angiotensin-converting enzyme2 (human)angiotensin-converting enzyme2 (human)angiotensin-converting enzyme2 (human)angiotensin-converting enzyme2 (human)bradykininedemanitric oxidenitric oxide